Life-threatening flash flooding escalated across the South and Ohio Valley this weekend, as extreme rainfall triggered a "generational" event. At least 16 people have died as a result of the days-long outbreak of destructive weather.

Ten deaths have been confirmed in Tennessee alone, as well as two in Kentucky and two in Missouri. Arkansas and Indiana each reported one death. With the weather still unfolding, officials are bracing for more casualties.

In Arkansas, flooding ripped apart a railroad bridge causing a train to derail and tumble into the rising river below.

In Kentucky, hundreds of roads have been closed due to rising floodwaters, mudslides, and rockslides, leaving many communities cut off from vital services. Officials are urging residents to avoid travel unless evacuating.

A tornado was confirmed Saturday evening in northern Mississippi, east of Oxford. There were no immediate reports of serious damage or injuries.

The storms are not showing signs of letting up. Local authorities have declared a state of emergency in multiple areas as swollen rivers and saturated ground continue to pose an overwhelming threat. Emergency response teams are stretched thin, working in dangerous conditions to rescue stranded residents.

The situation is compounded by the possibility of more tornadoes, which have already devastated parts of the region, and the ongoing threat of damaging winds and hail.